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Digital Technologies in Clinical Trials: Just-in-time Adaptive Interventions, Dynamic Treatment Regimes, and Missing Data in Digital Outcomes


Chronic or cyclical conditions can sometimes require personalized approaches, as treatments may vary in efficacy, and patient response or adherence to their treatment can change over time. We now live in the digital age, and this means we have more opportunities to better measure, engage and treat the right person, with the right treatment, at the right time for them in real-time. Join us as we explore some of the complexities of building digital, adaptive interventions or incorporating digital measurements into clinical trials.

We will consider some of the methodological and statistical challenges of building adaptive interventions for chronic conditions, by introducing an example from a sequential multiple assignment randomized trial and discussing the implementation of a recent micro-randomized trial. We’ll also tackle the emerging issue of handling missing data in high-frequency measurements from wearables, using a physical activity trial as a case study. Don’t miss this in-depth discussion on digital interventions in clinical trials, advancing health behavior interventions and overcoming key research hurdles.

Register today.

The presenters

Dr Lauren Bell

Senior Statistician, Veramed

Dr Lauren Bell is a senior statistician at Veramed, where she is committed to providing robust and comprehensive statistical support to the study teams she collaborates with. She holds a PhD in the design of clinical trials, from The London School of Hygiene and Tropical Medicine, and has worked on adaptive trials at MRC-Biostatistics Unit, University of Cambridge. Lauren has a deep interest in partnering with clinical teams to develop digital interventions for long-term support to patients with chronic or cyclical conditions.

Dr Mia Tackney

Research Associate, University of Cambridge
Mia Tackney is a research associate at the MRC-Biostatistics Unit, University of Cambridge. Her work focuses on methodological challenges in the use of digital technologies to measure health outcomes in clinical trials. Previously, she worked at the London School of Hygiene and Tropical Medicine on methods for handling missing data for accelerometer outcomes.

Gwen Perry

Statistician II, Veramed

Gwen Perry joined Veramed’s Graduate Training Programme in 2021. Prior to joining, she completed a Master’s in Medical Statistics at UCL while also undertaking an NIHR Pre-Doctoral Fellowship, exploring adaptive treatment strategies for clinical trials with particular focus on SMART designs. At Veramed, Gwen supports client projects in oncology and is a part of the internal Culture Club, helping to protect Veramed’s people-focused culture.

Meet Veramed

Veramed is a pioneering CRO redefining intelligent healthcare decision-making through end-to-end biometrics. We bring together people, innovation, and technology together with world-class governance to accelerate evidence generation and advance patient health. With skilled statisticians and programmers uniquely matched and scaled to client needs, we produce exceptional deliverables swiftly using a blend of skill, rigorous governance, and automation to optimize the speed and success of clinical research from design to submission and beyond.

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